Development and validation of stability indicating HPLC method for quantification of tinidazole
نویسندگان
چکیده
منابع مشابه
Stability Indicating HPLC Method Development and Validation
High performance liquid chromatography (HPLC) is an integral analytical tool in assessing drug product stability. HPLC methods should be able to separate, detect, and quantify the various drug-related degradants that can form on storage or manufacturing, plus detect and quantify any drug-related impurities that may be introduced during synthesis. Forced degradation studies of new chemical entit...
متن کاملDevelopment and validation of stability-indicating HPLC method for simultaneous determination of meropenem and potassium clavulanate.
A stability-indicating LC assay method was developed and validated for a simultaneous determination of meropenem and potassium clavulanate in the presence of degradation products formed during acid-base hydrolysis, oxidation and thermolysis. The isocratic RP-HPLC method was developed with a LiChrospher RP-18 (250 mm x 4.6 mm, 5 microm) column and gradient elution of 12 mmol/L ammonium acetate a...
متن کاملDevelopment and Validation of Stability Indicating Rp-hplc Method for Determination of Β-acetyldigoxin
Objective: The objective of the present study was to develop and validate a novel stability indicating reverse phase-high performance liquid chromatography (RP-HPLC) method for determination of β-acetyldigoxin, an active pharmaceutical ingredient (API). Methods: The chromatographic separation was carried out on Agilent Technologies 1200 series HPLC system equipped with photo diode array detecto...
متن کاملDevelopment and Validation of Stability indicating RP-HPLC Method for the estimation of Azithromycin Suspension
A RP-HPLC method was developed and validated for quantitative determination of azithromycin in pharmaceutical suspension dosage forms. The chromatography was carried out on a Phenomenex C 18 (150 x 4.6 mm i.d., 5μ) column with Acetonitrile: 0.5 % Formic acid as mobile phase (Isocratic A: B = 40: 60 % v/v), at 215 nm detector wave length with a flow rate of 1 ml/min. Clarithromycin was used as a...
متن کاملDevelopment and validation of stability-indicating HPLC method for determination of cefpirome sulfate.
The stability-indicating LC assay method was developed and validated for quantitative determination of cefpirome sulfate (CPS) in the presence of degradation products formed during the forced degradation studies. An isocratic HPLC method was developed with Lichrospher RP-18 column, 5 μm particle size, 125 mm x 4 mm column and 12 mM ammonium acetate-acetonitrile (90 : 10 v/v) as a mobile phase. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Chemistry
سال: 2019
ISSN: 2153-2257,2153-2249
DOI: 10.5155/eurjchem.10.2.102-107.1813